MAVYRET is a prescription medicine used to treat adults and children 12 years of age and older or weighing at least 99 pounds (45 kilograms) with:
- chronic (lasting a long time) hepatitis C virus (hep C) genotypes 1, 2, 3, 4, 5 or 6 infection without cirrhosis or with compensated cirrhosis.
- Hep C genotype 1 infection and have been previously treated with a regimen that contained a hep C NS5A inhibitor or an NS3/4A protease inhibitor (PI), but not both.
MAVYRET contains the 2 medicines: glecaprevir and pibrentasvir.
Treatment with MAVYRET does not require the addition of ribavirin.
It is not known if MAVYRET is safe and effective in children under 12 years of age.
The hep C virus can make about a trillion copies per day. MAVYRET is a combination of 2 medications, glecaprevir and pibrentasvir, that work together to help stop the hep C virus from multiplying.
Learn more about how MAVYRET works to cure* all types of hep C.
MAVYRET can cause serious side effects, including:
Hepatitis B virus (hep B) reactivation. Before starting treatment with MAVYRET, your doctor will do blood tests to check for hep B infection. If you have ever had hep B infection, hep B could become active again during or after treatment for hep C with MAVYRET. Hep B that becomes active again (called reactivation) may cause serious liver problems, including liver failure and death. Your doctor will monitor you if you are at risk for hep B reactivation during treatment and after you stop taking MAVYRET. For more information about side effects, see the section “What are the possible side effects of MAVYRET?”
MAVYRET is the only 8-week treatment for those with GT 1–6, who have not been previously treated, without cirrhosis or with compensated cirrhosis and who have not received a liver or kidney transplant.
You may take MAVYRET for 8, 12, or 16 weeks depending on your hep C genotype, previous hep C treatment experience, if you have compensated cirrhosis, and if you have had a liver or kidney transplant. Your doctor will tell you how long you need to take MAVYRET.
“Cured” means that hep C is no longer detectable in your blood 3 months after you finish your hep C treatment with MAVYRET. Individual results may vary.
Twelve weeks after you complete your treatment, your doctor will do a blood test to determine if the hep C virus can still be detected.
What to know before starting treatment with MAVYRET
Before taking MAVYRET, tell your doctor about all of your medical conditions, including if you:
- have had hepatitis B virus infection
- have liver problems other than hep C virus infection
- have HIV-1 infection
- have had a liver or a kidney transplant
- are pregnant or plan to become pregnant. It is not known if MAVYRET will harm your unborn baby
- are breastfeeding or plan to breastfeed. It is not known if MAVYRET passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take MAVYRET
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Do not take MAVYRET if you:
- have certain liver problems
- also take any of the following medicines:
MAVYRET and other medicines may affect each other. This can cause you to have too much or not enough MAVYRET or other medicines in your body. This may affect the way MAVYRET or your other medicines work, or may cause side effects.
Keep a list of your medicines to show your doctor and pharmacist.
- You can ask your doctor or pharmacist for a list of medicines that interact with MAVYRET
- Do not start taking a new medicine without telling your doctor. Your doctor can tell you if it is safe to take MAVYRET
with other medicines
MAVYRET can be used by people with chronic kidney disease. Your doctor will tell you if MAVYRET is right for you and how long you will need to take it.
MAVYRET is covered by most insurance plans.
If you have commercial insurance, you may be eligible to pay as little as $5 a month. Restrictions apply.
Visit our cost page to learn more or call us at 1-877-628-9738 with any questions.
What to know while taking MAVYRET
Take 3 pills at one time each day with food. Take MAVYRET exactly as your doctor says. Never change your dose, skip or miss doses, or stop taking MAVYRET without your doctor's help.
If you do miss a dose, and it's:
- Less than 18 hours, take the missed dose with food as soon as you can. Then take your next dose at the usual time
- More than 18 hours, do not take your missed dose. Take your next dose as usual, with food
If you take too much MAVYRET, call your doctor or go to the nearest hospital emergency room right away.
MAVYRET can cause serious side effects, including:
Hepatitis B virus reactivation. See “What is the most important information I should know about MAVYRET?”
In people who had or have advanced liver problems before starting treatment with MAVYRET: rare risk of worsening liver problems, liver failure, and death.
Your doctor will check you for signs and symptoms of worsening liver problems during treatment with MAVYRET.
The most common side effects of MAVYRET include headache and tiredness.
These are not all the possible side effects of MAVYRET.
- Store MAVYRET at or below 86°F (30°C)
- Keep MAVYRET in its original blister package until you are ready to take it
Keep MAVYRET and all medicines out of the reach of children.
- Tell your doctor and pharmacist about your travel plans
- Pack more medicine than you think you'll need so you're always prepared
- Pack MAVYRET in your carry-on baggage so it's always with you
For any questions about drinking alcohol while taking MAVYRET, please talk to your doctor.